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KMID : 1149220200280030271
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Korean Journal of Oriental Medical Prescription
2020 Volume.28 No. 3 p.271 ~ p.280
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Beneficial effects of Paeo-tang on cardiovascular and renal function in L-NAME-induced hypertensive rats
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Na Se-Won
Hong Mi-Hyeon
Kim Hye-Yoom
Jang Youn-Jae
Yoon Jung-Joo
Lee Yun-Jung
Kang Dae-Gill
Lee Ho-Sub
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Abstract
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Hypertension has been approved to cause disharmony between the heart and kidney such as cardiac hypertrophy and kidney dysfunction. In traditional oriental medicine Paeo-tang (PET) has been shown to have effects on blood circulation improvement. However, the beneficial effect of PET on hypertension remains unknown. In this study, we investigated that PET attenuates blood pressure and improves cardiovascular and renal function in NG-nitro-L-arginine methylester (L-NAME) rat model. Hypertensive rat models were induced by the administration of L-NAME (40 mg/kg/day) and then PET (50 or 100 mg/kg/day) or Olmetec was treated for 2 weeks. PET treatment significantly suppressed the systolic blood pressure and decreased intima-media thickness in the thoracic aorta. PET ameliorated endothelium-dependent and independent vascular relaxation in the L-NAME-induced vascular dysfunction. PET ameliorated the functional decline in the kidney such as albumin and blood urea nitrogen in plasma. These results demonstrated that PET possesses protective effects against L-NAME-induced hypertension.
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KEYWORD
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Paeo-tang, L-NAME, Hypertension, renal dysfunction
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